| || |
Special Internet Prices.
Fast & Guaranteed Worldwide Delivery!
Secure & FAST Online Ordering.
Our Drugstore Is The Most Trusted Online Drug Supplier.
Related post: E.L Tadapox Online Murphy Medical Staff Fellow EPB, NCI
T. Nash Senior Investigator LPD, NIAID
E. Ottesen Senior Investigator LPD, NIAID
COOPERATING UNITS (It any)
Univ. of California at San Francisco, Dept. Pathology (J. McKen-ow); SEMA, Inc., Rockville (G.
Phillips); Merck, Sharpe, Dohme. Rahway, NJ (K. Brown).
Laboratory of Parasitic Diseases
Cell Biology and Immunology
INSTTTUTE ANO LOCATION
NIAID, NIH. Bethesda. MD 20892
PROFESSIONAL: I OTHER:
0.8 I 0.5
CHECK APPROPRIATE 80X(ES)
S. (a) Human subjects D (b) Human tissues D (c) Neither
D (al) Minors
D (a2) Interviews
SUMMARY OF WORK (Ua» jfntiun unrMueaa typa. Oo mx (jnMtf trm tpaem pmnOuO.)
This project involves clinical and immunologic studies of humans infected witl> the intestinal
nematode, Stronqyloides stercoralis , and parallel studies in an experimental host, the patas
monkey. Research on this parasite is justified because human infections occur in substantial
numbers even in the U.S., it often goes undiagnosed and can produce fatal outcome in
immunosuppressed people, and it is a parasite with unusual biologic properties.
A good portion of the somatic and E/S antigens obtained from infected patas monkeys in
the past year is being stockpiled for a new batch of skin test antigen. Antigenic analysis of
infective larvae (L3) has focused heavily upon identification and characterization of a protease
present in both somatic and E/S antigens. It is a metallo-protease, with functional activity
demonstrable at about 30, 60, and 90 kO, suggesting a trimeric form. The protease is also
allergenic - i.e., it causes histamine release from IgE sensitized basophils in-vitro. Monoclonal
antibodies raised to somatic larval antigen have been relatively weak in identifying antigens, and
IgE Western blots are faint so that these reagents and approaches have not been as useful as
expected. The possibility that HTLV-1 infection may selectively impair immune responses
important for control of strongyloidiasis in some patients is being investigated.
PHS 9040 (Rn* V84) SPO*i«.«i*
OCPARTMCNT or HtALTW ANO HUMAN SERVICES OUBLiC HEALTH SERVICE
NOTICE OP INTRAMURAL RESEARCH PROJECT
Z01 Al CC277-05 L?D
Cctober 1. 1987 ;o Seoterr.Der 30. 1988
Mecrianism of Senjm Resistance in Bactena
PI: K. Joiner Senior Investigator LPD. NIAID
Others: J.E. Schweinle IPA LPD. NIAID
zocnM-rtta -,nits * ••d
Andrea Tenner, Amencan Red Cross
Latocratory of Parasitic Diseases .
Unit of Microbial Pathogenesis
(«3TnVr| AMO LOCATION 1
NIAID, NIH, Bethesda. MD 20892 1
IZTAL «AAN.»eAMS. <»«0«5S«NA4_
0.2 i 0.2
C (a) Human suO|«cts £ (b) Human tissues
iZ (al) Minors
_ (a2) Interviews
C (c) Ne«ttier
Studies were completed on tMe opsonic and bactericidal activity of a monocional antibody
directed agajnst the outer membrane proteolipid. H.8. of Neisseria oonontioeae . In addition to its
anti-gonococcal and opsonic activity described in earlier reports, it was found to ovemde the
regulatory function of the serum glycoprotein CI inhibitor and to allow activation of Cl with
sequentiaJ activation of the classicaJ complement pathway. Despite earty suggestions that
Neissena gonorrhoeae directly Buy Tadapox activated the classical complement pathway, meticulous stijdies
prohibiting spontaneous activation of CI by autocatalytic mechanisms proved otherwise.
Qualitative measurement of state of activation of Cis proved tiiat Neisseria oonontioeae does not
directly activate the dassicaJ complement pathway in the absence of antibody whether or not CI
inhibitor is present When antibodies are included in the assay, activation always occurs.
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBUC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
Z01 A! 00347-06 LPD
October 1 , 1 987 to September 30, 1 988
TITLE OF PROJECT (30 ctwtcmn or maa. fitla must M on onm iin* oeiwaan rn» oomrs.)
Studies on Schistosomal Hepatic Fibrosis
PRINCIPAL INVESTIGATOR (Ust ointf pnttaaiontt p»nenml otiew ma Pnnapal Invaangator j iNama. ma. laooraiory. ano inaonita tfhiiaaoni
PI: A. W. Cheever Assistant Chief LPD, NIAID
R. H. Duvall
Bio. Lab. TecH.
Bio. Lab. Tech. (Micro.)
Head, Immunology Section
Senior Staff Fellow
Related links: erythromycin stearate price, retin-a micro 0.1 gel, cheap accutane india, femara vs generic letrozole, Online Doxycycline, plendil generic equivalent, best place to buy accutane online, 120 mg of prozac too much, xtreme south african hoodia, 875 mg augmentin strong
| || |